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https:///mymemo.xyz/wiki/api.php?action=feedcontributions&feedformat=atom&user=218.45.36.24 2024-05-26T09:05:40Z 利用者の投稿記録 MediaWiki 1.31.0 2014-07-03T04:07:21Z

<p>218.45.36.24: /* 関連項目 */</p> <hr /> <div>{{Drugbox<br /> | name = ジメルカプロール <br /> | image = (±)-Dimercaprol Enantiomers Structural Formulae.svg<br /> | IUPAC_name = (&#039;&#039;RS&#039;&#039;)-2,3-ジメルカプロール <br /> | CAS_number= 59-52-9<br /> | ATC_prefix = V03<br /> | ATC_suffix = AB09<br /> | PubChem=3080<br /> | DrugBank=<br /> | KEGG = D00167<br /> | C=3 | H=8 | O=1 | S=2<br /> | smiles = OCC(S)CS<br /> | molecular_weight = 124.227<br /> | NFPA Rating = Health - 2;Flammability - 1;Reactivity - 0<br /> | Boiling point = 120 °C<br /> | Liquid density = 1.243 g/cm&lt;sup&gt;3&lt;/sup&gt;<br /> | Appearance = 無色の油状液体<br /> | Alternate names = 1,2-ジチオグリセロール&lt;br /&gt;メルカプトール&lt;br /&gt;ジカプトール&lt;br /&gt;スルファクチン<br /> }}<br /> &#039;&#039;&#039;ジメルカプロール&#039;&#039;&#039;（dimercaprol）は、[[重金属]][[中毒]]の解毒剤（[[キレート剤]]）である。商品名は&#039;&#039;&#039;バル&#039;&#039;&#039;（BAL）であり、元々は[[イギリス]]で[[ルイサイト]]の解毒剤として開発されたことに由来する（&#039;&#039;British Anti-Lewisite&#039;&#039;の略称）。<br /> <br /> [[組成式]]はC&lt;sub&gt;3&lt;/sub&gt;H&lt;sub&gt;8&lt;/sub&gt;OS&lt;sub&gt;2&lt;/sub&gt;、[[IUPAC名]]は2,3-ジメルカプトプロパノール(2,3-Dimercaptopropanol)。[[CAS登録番号]]は59-52-9。 <br /> <br /> ==作用機序==<br /> 投与方法は筋注。本剤は、[[金属]][[イオン]]に対する親和性が強く、体内の諸[[酵素]]と金属イオンの結合を阻害する。既に結合してしまっている場合は、本剤が金属イオンと結合することによって、阻害された酵素から金属イオンを引き剥がし、体外への排泄を促進する。その結果、酵素の活性が賦活する。<br /> <br /> ==適応==<br /> [[ヒ素|砒素]]、[[水銀]]、[[鉛]]、[[銅]]、[[金]]、[[ビスマス]]、[[クロム]]、[[アンチモン]]の中毒。なおモノアルキル水銀、アルキル鉛、[[タリウム]]、[[バナジウム]]に対しては効果がない。<br /> <br /> [[鉄]]、[[カドミウム]]、[[セレン]]、[[放射性同位体|放射性元素]]の中毒には用いない（中毒症状を悪化させることがある）。なお、鉄中毒に対しては[[デフェロキサミン]]、カドミウム中毒にはCaNa2[[EDTA]]が用いられる。<br /> <br /> ==関連項目==<br /> *[[化学兵器]]<br /> *[[中毒]]<br /> **[[農薬中毒]]<br /> *[[アトロピン]]<br /> **[[プラリドキシムヨウ化メチル]]<br /> <br /> {{DEFAULTSORT:しめるかふろる}}<br /> [[Category:チオール]]<br /> [[Category:アルコール]]<br /> [[Category:解毒剤]]<br /> [[Category:キレート剤]]<br /> [[Category:WHOエッセンシャルドラッグ]]<br /> <br /> {{Pharm-stub}}</div>

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