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<div>'''サプレッサー突然変異'''(サプレッサーとつぜんへんい)とは、1か所の突然変異の効果が第2の突然変異によって、遮蔽される遺伝子変異。<br />
<br />
例えば、物質Aの産生に関する酵素の一つが不活性化されたとすると、その後のサプレッサ変異で,再び活性をもつこの酵素の合成回復させ、物質Aが産生出来るようにする。サプレッサ突然変異は2つに分類することができる。<br />
<br />
== 遺伝子内サプレッション ==<br />
最初の変異と同じ遺伝子内の違う部位に起こる。<br />
フレームシフトが例に挙げられる。<br />
{| class="wikitable"<br />
|+ 正常配列<br />
! DNA !! 5'-CGA !! CGA !! CAC !! TCA !! CGA !! CGA -3'<br />
|-<br />
! mRNA !! 5'-GCU !! GCU !! GUG !! AGU !! GCU !! GCU -3'<br />
|-<br />
! アミノ酸 !! [[アラニン|Ala]] || Ala || [[バリン|Val]] || [[セリン|Ser]] || Ala || Ala<br />
|}<br />
{| class="wikitable"<br />
|+ 1回目の変異配列(欠失)<br />
! DNA !! 5'-CGA !! CGA !! ACT !! CAC !! GAC !! GA -3'<br />
|-<br />
! !! 5'-GCU !! GCU !! UGA !! !! !! <br />
|-<br />
! アミノ酸 !! Ala || Ala || 終止 || || || <br />
|}<br />
{| class="wikitable"<br />
|+ 2回目の変異(挿入)<br />
! DNA !! 5'-CGA !! ACG !! AAC !! TCA !! CGA !! CGA -3'<br />
|-<br />
! mRNA !! GCU !! UGC !! UUG !! AGU !! GCU !! GCU <br />
|-<br />
! アミノ酸 !! Ala || [[システイン|Cys]] || [[ロイシン|Leu]] || Ser || Ala || Ala<br />
|}<br />
この場合、最初のフレームシフトが打ち消されてしまう。よって、サプレッサ突然変異。<br />
<br />
== 遺伝子間サプレッション ==<br />
最初の変異と違う遺伝子間に起こる。変異遺伝子の塩基配列を変えるのではなく、mRNAの読まれ型を変える。有名な例で言えば、アンチコドンが変異を起こした変異tRNAである。例えば、大腸菌には終止コドン(UAA,UAG,UGA)に対して、アミノ酸のコドンとして読み取るサプレッサー遺伝子がある。これらは、本来ならUAGで終止コドンであるところにSer,Glu,Tyrを取り込ませる。<br />
<br />
== 関連項目 ==<br />
*[[遺伝子]]<br />
*[[進化]]<br />
*[[腫瘍]]<br />
*[[染色体異常]]<br />
*[[翻訳 (生物学)]]<br />
*[[DNA修復]]<br />
*[[突然変異]]<br />
<br />
{{DEFAULTSORT:さふれつさとつせんへんい}}<br />
[[Category:遺伝学]]<br />
[[Category:病理学]]<br />
{{biosci-stub}}<br />
{{medical-stub}}</div>192.244.210.24 Warning: Cannot modify header information - headers already sent by (output started at /home/users/1/sub.jp-asate/web/wiki/extensions/HeadScript/HeadScript.php:3) in /home/users/1/sub.jp-asate/web/wiki/includes/WebResponse.php on line 46